RNase Inhibitor

This product is a recombinant type human ribonuclease inhibitor purified using a combination of ion exchange and affinity chromatography.

RNase Inhibitor

EC Number


Origin: Escherichia coli, Recombinant

This inhibitor exhibits broad-spectrum RNase inhibitory properties, including RNase A, RNase B, RNase C and human placental RNase. Does not inhibit RNase T1, S1 nuclease, RNase from Aspergillus, and RNase H. The 50kDa protein exerts its inhibitory effect by noncovalently binding to RNases in a 1:1 ratio. This inhibitor can be applied to a reverse transcriptase reaction.

Key Specifications

  • Concentration/Activity**: 40 U/µl
  • Purity: ≥90%
  • RNase Activity: None detected
  • Endonuclease Activity: None detected
  • Exonuclease activity: None detected

** One unit is defined as the amount of RNase inhibitor required to inhibit the activity of 5 ng of ribonuclease A by 50 %.

Key Characteristics

  • Stabilizes RNA in a cDNA synthesis or a RNA synthesis reaction
  • Does not inhibit SP6, T7 or T3 RNA Polymerase, AMV or M-MLV Reverse Transcriptase, or Taq DNA Polymerase
  • Exhibits broad-spectrum RNase inhibitory properties
  • Active over a broad pH range (pH 5–8)
Product Available in select countries in the following territories:

Asia (only in select countries), Europe, USA

Ordering Information

Name Size Part Package Insert
RNase Inhibitor 2.5KU 62.5µL (2,500U) RNase Inhibitor SIN-201 N/A
RNase Inhibitor 100KU 2.5mL (100KU) RNase Inhibitor (Bulk) SIN-229 N/A
RNase Inhibitor 1,000KU 25mL (1,000KU) RNase Inhibitor (Bulk) SIN-259 N/A

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