Creatine Kinase

Elevated concentrations of serum creatine kinase are found in all types of muscular dystrophy and disease involving the destruction of muscle tissues. In the case of progressive muscular dystrophy, elevated CK concentrations may be present before clinical symptoms appear. Elevated CK concentrations are observed after myocardial infarction and in cases of acute cardiovascular disease and Reye’s Syndrome. Neurogenic muscle diseases such as multiple sclerosis and polio do not produce elevated CK concentrations. CK activity is in inverse relation to thyroid activity, thus, in cases of hypothyroidism, elevated concentrations of CK would be observed.