ARK™ EDDP Assay

Methadone (DOLOPHINE®) is a synthetic opioid indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. It is a Schedule II substance under the United States Controlled Substances Act for its potential for abuse and risk of dependence.

Methadone is metabolized to a variety of inactive metabolites, including the primary metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP). EDDP is therefore a useful marker in identifying methadone.

The ARK™ EDDP Assay is an immunoassay intended for the qualitative and/or semiquantitative determination of EDDP in human urine at a cutoff concentration of 100 ng/mL and 300 ng/mL.